SUEZ Water - Water Technologies & Water

Sievers 500 RL On-Line TOC Analyzer

Reliable, accurate performance for online TOC monitoring and real-time testing

Used extensively in the pharmaceutical industry, the Sievers 500 RL On-Line TOC Analyzer offers unmatched stability and performance. It provides online TOC analysis for compliance with USP <643> and other global pharmacopeia and can be provided with the critical protocols required for real-time testing (RTT) process validation. Specific features are offered for pharmaceutical applications, such as automated validation and system suitability testing, the ability to measure USP <645> conductivity, and compliance with 21 CFR Part 11. The 500 RL uses the most robust analytical technology available and is easy to implement and maintain.

Sievers 500 RL On-Line TOC Analyzer

Reliable, accurate performance for online TOC monitoring and real-time testing

Used extensively in the pharmaceutical industry, the Sievers 500 RL On-Line TOC Analyzer offers unmatched stability and performance. It provides online TOC analysis for compliance with USP <643> and other global pharmacopeia and can be provided with the critical protocols required for real-time testing (RTT) process validation. Specific features are offered for pharmaceutical applications, such as automated validation and system suitability testing, the ability to measure USP <645> conductivity, and compliance with 21 CFR Part 11. The 500 RL uses the most robust analytical technology available and is easy to implement and maintain.

Pharmaceutical Industry Compliance

The Sievers 500 RL is engineered to meet stringent global regulatory requirements in the pharmaceutical industry, including USP <643>, EP 2.2.44 Total Organic Carbon, IP 2.4.30, CP Appendix VIII R, and JP16 2.59 monographs for Purified Water and Water for Injection. Sievers DataGuard software facilitates compliance with 21 CFR Part 11.

Features & Benefits

500 RL On-Line Features & Benefits

  • Online monitoring and real-time testing
  • Wide applications range, includes high and/or unstable conductivity waters- up to 25 μS/cm
  • Minimal preventative maintenance (typically just a few hours per year)
  • 12-month calibration stability
  • Fully automated validation protocols, including system suitability testing and calibration (with the optional Super iOS)
  • Automated transfer of standards data, including concentration, lot number, and expiration date to the analyzer (with the optional Super iOS)
     

Specifications

500 RL On-Line Specifications

Total Organic Carbon*

Linear Range 0.03 to 2,500 ppb as C
Precision < 1% RSD or 0.03 ppb as C, whichever is greater
Accuracy ± 5% of measurement
pH Range 5.5 to 8.0 in order to meet accuracy specification
Analysis Modes On-line, on-line averaged, on-line timed
Analysis Time Continuous mode: 6 minutes
Average and timed modes: 0.5, 1, 4, 8, or 24 hours
Ozone Compatibility** Maximum 200 ppb as O3
External Flow Rate Minimum 50 mL/min
Sample Temperature 1–95 °C (34–203 °F)
Sample Pressure Up to 100 psig
Interferences Insensitive to organic heteroatoms
Calibration Stability Typically 12 months
Display Readout 3 significant digits

Conductivity*

Raw Conductivity Range*** 0.01 to 35 µS/cm
Conductivity Accuracy**** ± 0.005 µS/cm or ± 1%, whichever is greater
Conductivity Precision <0.25% RSD
Maximum Sample Conductivity 25 µS/cm at neutral pH

Instrument*

Power Universal Power Supply: 100–240 ± 10% VAC, 50 W, 50/60 Hz
Ambient Temperature 10–40°C (50–104°F)
Maximum Relative Humidity Up to 95%, noncondensing
Maximum Altitute 2,300 m (7,546 ft)
Inputs One isolated binary input
Outputs Three isolated 20mA outputs, one Serial RS-232 output, one USB port, one parallel printer port, and four alarm outputs
Installation/Overvoltage Category II (protects against transients present in Category II power)
Safety Certifications

ETL, CE see Declaration of Conformity (base) 
           see Declaration of Conformity (Super iOS) 

Pollution Degree 2 (normally only non-conductive pollution)
Display Backlit Quarter-VGA touchscreen display
Dimensions H: 41.9 cm (16.5 in); W: 48.3 cm (19 in); D: 27.4 cm (10.8 in)
Weight 16.9 kg (37.2 lb)
IP Rating Environmental Enclosure:  IP-45

The UV lamp inside this product contains mercury and must be recycled or disposed of in accordance with local, state, and federal laws.

* Stated analytical performance is achievable under controlled laboratory conditions that minimize operator and standards errors.
** The sample temperature and pressure should not simultaneously exceed 60 °C and 100 psi. 
*** Ozone: 50 ppb continuous, conductivity accuracy ±0.02 µS/cm < 1.0 µS/cm, ±2% >1.0 µS/cm; 200 for 2 hours once/day, conductivity readings not within spec, recovery time to in-spec readings: 2 hours
**** With optional USP <645> conductivity measurement

Accessories

500 RL On-Line Options & Accessories

  • Standard Integrated On-Line Sampling System (iOS): Designed to easily switch sampling methods between on-line and grab, and for introducing standards used for calibration and system protocols

  • Super iOS: Has four vial ports and cartridge to fully automate calibration and pharmaceutical system protocols, eliminating human error and reducing labor time

  • DataShare 500: allows multiple parties to securely share and review protocol data and reports with signature fields

  • DataGuard Software: Full compliance support for 21 CFR Part 11 and Annex 11

Learn how the 500 RL makes online TOC analysis in pharma easier

 

*A trademark of SUEZ. May be registered in one or more countries.